General Cell Based Assays
Eurofins Discoverx InCELL Hunter eXpress BLK Kinase Binding Assay, 2pl Kit. (96-0044E1CP0M)
The InCELL Hunter eXpress BLK Kinase Binding Assay provides an easy-to-use cell based assay to study small molecule drug candidates that engage with kinases. This kit assesses compound-engagement-based stabilization of BLK via detection of BLK levels. This product uses EFC technology. The cell line included overexpresses BLK target protein fused to ProLabel. In the absence of compound that binds and stabilizes the target, this protein is degraded and no EFC signal is produced. When compound engages and stabilizes the target, EA contained in the detection reagent produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Aat Bioquest Cell Navigator Lysosome Staining Kit Green Fluorescence (500 Tests)
Our Cell Navigator fluorescence imaging kits are a set of fluorescence imaging tools for labeling sub-cellular organelles such as membranes lysosomes mitochondria and nuclei etc. This catalog is for 500 Tests.
Cayman Chemical LIpIdLaunchLNP-0315 Uptake 1ea
Cayman’s LipidLaunch™ LNP-0315 Uptake Kit (Green Fluorescence) is intended to serve as a starting point for laboratories to explore the uptake of LNPs by their target cell type without the need for specialized equipment. Optimal preparation conditions for the encapsulation of nucleic acids with LNPs must be determined by the end user.
Abcam Wound Healing Assay
Wound Healing Assay
The product is subject to the following: Abcam Restricted Use Statement
ABclonal Technology Cathepsin B Rabbit pAb
This gene encodes a member of the C1 family of peptidases. Alternative splicing results in multiple transcript variants, with at least one encoding a preproprotein that is processed into cathepsin B light and heavy chains, which dimerize to form the active enzyme. Cathepsin B is a lysosomal cysteine protease with endopeptidase and exopeptidase activity, involved in protein turnover. It also acts as amyloid precursor protein secretase, with incomplete APP processing linked to Alzheimers disease. Overexpression of this protein is associated with esophageal adenocarcinoma and other cancers. Both cathepsin B and L are involved in cleaving the spike protein of SARS-CoV-2 during cell entry. Multiple pseudogenes of this gene have been identified.
Abcam Lovastatin (Mevinolin), HMG-CoA reductase inhibitor, 50MG
MW 404.5 Da, Purity >98%. Potent, competitive HMG-CoA reductase inhibitor (Ki = 0.6 nM). Blood-brain barrier permeable. Inhibits in vivo and in vitro cholesterol biosynthesis. Also reduces α-synuclein levels in vitro and in vivo.
The product is subject to the following: Abcam Restricted Use Statement
Cell Biolabs Inc CytoSelect™ 24-Well Cell Migration Assay Kit (3 µm, Fluorometric), 12 assays
Chemotaxis, a type of cell migration, is a highly integrated, multistep process that orchestrates embryonic morphogenesis, tissue repair and regeneration. The initial response of a cell to a migration-promoting agent is to polarize and extend protrusions in the direction of the attractant; these protrusions can consist of large, broad lamellipodia or spike-like filopodia that are driven by actin polymerization and can be stabilized by extracellular matrix (ECM) adhesion or cell-cell interactions. The CytoSelect™ Cell Migration Assay Kit utilizes polycarbonate membrane inserts (8 µm pore size) to assay the migratory properties of cells. The kit contains twelve 3 um polycarbonate membrane inserts in a 24-well plate, through which migratory cells are able to pass. Cells are quantified using the provided fluorometric dye. The 3 µm pore size is optimal for measuring the migration of leukocytes.
Abcam BC 11 hydrobromide, Urokinase (uPA) inhibitor, 50MG
MW 290.97 g/mol, Purity >99%. Selective urokinase (uPA) inhibitor (IC₅₀ = 8.2 μM). Shows selectivity over 8 other related enzymes.
The product is subject to the following: Abcam Restricted Use Statement
Meso Scale Discovery U-PLEX Mouse IL-4 ASY
The Meso Scale Discovery U-PLEX Mouse IL-4 Assay Kit is a sensitive immunoassay for detecting and quantifying mouse interleukin 4 (IL-4) in samples like serum plasma and cell culture supernatant It uses MSD s electrochemiluminescent technology offering high sensitivity a wide dynamic range and quick results The assay detects IL-4 at 0 03 pg/mL with a 7-log range The kit includes a 96-well plate with capture antibodies detection antibodies and calibrators The assay completes in 3 5 hours after a 2-hour incubation providing a robust tool for research
Abcam MK886, Lipo x ygenase inhibitor, 50MG
MW 494.1 Da, Purity >98%. Potent 5-lipoxygenase activating protein inhibitor (FLAP) (IC₅₀ = 44 nM). Inhibits leukotriene biosynthesis (IC₅₀ = 2.5 nM) in vitro and tumor activity in vivo. Displays PPARα antagonist activity. Orally active in vivo.
The product is subject to the following: Abcam Restricted Use Statement
Meso Scale Discovery R-PLEX Human BMP-6 ASY
The R-PLEX Human BMP-6 Assay Kit from Meso Scale Discovery is an electrochemiluminescent immunoassay for the quantitative measurement of human Bone Morphogenetic Protein 6 (BMP-6) in serum plasma and cell culture supernatants The assay uses MSD s proprietary SECTOR Imager 6000 for high sensitivity detection The kit includes a 96-well plate coated with capture antibody detection antibody calibrator and sample diluent The assay has a range from 1 5 pg/mL to 1000 pg/mL and takes approximately 3 5 hours to complete This product can be used for biomarker research related to bone formation fracture healing and developmental disorders
Meso Scale Discovery R-PLEX Human E-Cadherin ASY
The R-Plex Human E-Cadherin Assay from Meso Scale Diagnostics is a multiplex immunoassay that measures E-Cadherin levels in human serum plasma and cell culture supernatants It utilizes electrochemiluminescence detection technology and provides high sensitivity up to 5 logs of dynamic range and low sample volume requirements This assay allows for the quantitative measurement of E-Cadherin an important biomarker that plays a role in cell adhesion and is often monitored in cancer research With minimal hands-on time this robust and reproducible assay generates rapid results using automated instrumentation
Eurofins Discoverx PathHunter eXpress CXCR3 CHO-K1 β-Arrestin GPCR Assays, 10-Plate Kit. (93-0271E2CP2L)
The PathHunter CXCR3 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. CXCL11/I-TAC) based activation of CXCR3 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged CXCR3 and EA-tagged β-Arrestin-2. Activation of CXCR3 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress ErbB4/ErbB4 Dimerization Assay, 10pl Kit. (93-0961E3CP5L)
The PathHunter ErbB4/ErbB4 Dimerization eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This kit assesses ligand (e.g. neuregulin-1 Beta 2) induced dimerization of ErbB4/ErbB4 receptors. This product uses EFC technology. The cell line included overexpresses ErbB4 target protein fused to PK alongside ErbB4 target protein fused to EA. Upon ligand-induced dimerization of ErbB4/ErbB4, detectable EFC signal is produced. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Microsolv Technology Corporation Base Plate, Translucent Polypropylene, Micro-Sample Management System, universal, re-usable. 12/CS.
Accommodates and holds one Micro-Sample Insert Rack in the U-2D System. Made of low weight polypropylene plastic, they comply with ANSI standards for 96 well plates. When used with Racks of Inserts, the unique molded bottoms allow each insert to be supported on the bottom. Use in a vortex mixer or water bath can be used with enhanced performance. Also most plate readers can be used. Bases are reusable and can be refrigerated.